This document is an applicability guide for the Payment Card Industry Data Security Standard (PCI DSS) version 4.0, specifically focusing on the Trend Vision One platform by Trend Micro, Inc. It outlines how the platform aligns with the security requirements set forth by PCI DSS for organizations that handle credit card data. The guide begins with an introduction to the PCI DSS and its purpose in enhancing payment security through defined security controls and processes. It details the applicability of Trend Vision One to various PCI DSS requirements, highlighting that it can support a range of security measures necessary for compliance. The document includes a summary of changes in PCI DSS 4.0, such as new requirements and clarifications aimed at improving risk mitigation. Additionally, it provides specific details on how Trend Vision One addresses these requirements, including network security controls, vulnerability management, and access control measures. The guide serves as a resource for organizations seeking to understand the compliance capabilities of Trend Vision One in relation to PCI DSS.