Achievability of Single Cell Lipidomics with Xevo MRT Mass Spectrometer

This research article explores the feasibility of single cell lipidomics using the Xevo™ MRT Mass Spectrometer. It highlights the high sensitivity, dynamic range, and mass accuracy of the system, enabling the identification of up to 180 lipids from a single THP-1 cell. The study emphasizes the importance of single cell analysis in understanding cellular heterogeneity and provides detailed methodologies for sample preparation, liquid chromatography, and mass spectrometry.