Analysis of PFAS in Animal Products Using LC-MS/MS Method

This technical report presents an analysis of per- and polyfluoroalkyl substances (PFAS) in animal products, specifically focusing on fish, using an enhanced sensitivity LC-MS/MS method. The study outlines the development of a UPLC method that improves time efficiency and sensitivity for detecting PFAS in food samples. The report details the methodology, including sample preparation and the use of a UniSpray ionization source, which significantly increases the response for PFAS analytes. The performance of the method was assessed using reference materials, achieving recoveries within the tolerances set by the EURL POPs PFAS guidance document. The report also discusses the implications of PFAS contamination in food and the regulatory context, including recent EU legislation on maximum residue levels. The findings indicate that the updated method allows for reduced analysis time and improved confidence in results, addressing concerns regarding dietary exposure to PFAS. Overall, the report provides a comprehensive examination of the methodology and its effectiveness in analyzing PFAS in animal-derived food products.