Sample Preparation and Analysis Workflow for PFAS Regulation

This guide presents a comprehensive workflow for sample preparation and analysis to comply with the newly established PFAS National Primary Drinking Water Regulation in the United States. The regulation sets enforceable limits for six PFAS compounds in drinking water, with individual maximum contamination levels ranging from 4 to 10 ng/L. The document outlines the use of Waters solutions, including the Xevo TQ-S micro Mass Spectrometer and specific solid phase extraction cartridges, to achieve the required sensitivity and accuracy for detecting PFAS levels. It details the methodologies EPA 537.1 and EPA 533, which are essential for testing drinking water samples. The guide emphasizes the importance of proper sample preparation to enhance method sensitivity and ensure reliable results. It also discusses the monitoring requirements for public water systems and the need for routine testing to meet regulatory standards. The document concludes by summarizing the effectiveness of the proposed workflow in achieving compliance with the new regulations.