This whitepaper discusses the concept of innovation at scale, particularly in the context of large established organizations (LEOs) facing challenges in driving innovation. It outlines the urgency for businesses to adapt quickly in response to global changes, such as those brought about by the pandemic. The document emphasizes the need for a shift in organizational approaches to problem-solving, advocating for a Challenge Driven Innovation® framework that enhances the effectiveness and efficiency of innovation processes. Key components of this framework include decentralized decision-making, unleashing human potential, and utilizing the right tools. The paper also addresses common pitfalls organizations encounter when attempting to innovate, such as risk aversion and the tendency to focus on low-value ideas rather than significant problems. By fostering a culture of innovation and redefining how problems are approached, organizations can improve their innovation outcomes and maintain a competitive edge.