Quantitative Monitoring of Solvent Concentration and Moisture Content

This research article discusses a novel method for quantitatively monitoring solvent concentration and moisture content during flow synthesis. Utilizing a micro-flow cell and near-infrared spectroscopy, the study demonstrates how to achieve accurate measurements with low standard deviations, essential for optimizing chemical reactions. The findings highlight the method's potential for in-line monitoring, improving efficiency in the synthesis of complex compounds, particularly in pharmaceutical a