Advancing Intracranial Tumor Treatment Through Gyroscopic Radiosurgery-Based Lattice Therapy

This document is a case series study that evaluates the feasibility, safety, and early clinical outcomes of lattice radiotherapy (LRT) delivered via the gyroscopic radiosurgery platform ZAP-X in patients with recurrent glioblastoma multiforme (GBM). The study involved four patients who received single-fraction LRT with a prescribed dose of 20 Gy to each lattice vertex. The treatment aimed to deliver high-dose vertices within the gross tumor volume while minimizing exposure to surrounding healthy tissue. Clinical and radiological evaluations were conducted at 1 and 3 months post-treatment. Results indicated that LRT was successfully delivered in all cases, with favorable treatment tolerability and no acute neurotoxicity observed. Early imaging showed radiological response or disease stabilization in three patients. The findings suggest that ZAP-X-based LRT is a feasible reirradiation option for heavily pretreated GBM patients, potentially improving local control without increasing toxicity. The study sets the groundwork for future prospective trials to further explore LRT's clinical efficacy and immunomodulatory role in neuro-oncology.