The ZS Medical Affairs Outlook Report 2025 is a white paper that examines the evolving landscape of medical affairs within the pharmaceutical industry. It addresses the need for medical affairs organizations to adapt to rapid advancements and the diverse needs of an expanding stakeholder network. The report outlines key trends identified through surveys of over 200 medical affairs professionals and 150 key opinion leaders (KOLs). It details the evolution of medical affairs organizations, the external perception of pharmaceutical companies, and priority investment areas, including digital engagement platforms and insights collection. The report also discusses the importance of patient-centric strategies, emphasizing that maintaining a focus on patient outcomes is crucial for fostering meaningful interactions and driving clinical practice changes. Additionally, it highlights the role of technology and generative AI in enhancing medical affairs capabilities. Overall, the report serves as a comprehensive resource for medical affairs organizations seeking to engage effectively with stakeholders and create impact in the industry.