This guide presents predictions for the Emergency Medical Services (EMS) sector in 2022, focusing on the ongoing effects of COVID-19. It outlines key trends and challenges, including staffing difficulties exacerbated by The Great Resignation, which has led to agencies offering substantial signing bonuses to attract paramedics. The document emphasizes the need for agencies to adapt their engagement models, enhance training, and provide flexible scheduling to support staff well-being. It also discusses the rise of telemedicine and remote learning as permanent fixtures in patient care and training. Furthermore, it highlights the necessity for new performance measures that prioritize patient outcomes over traditional metrics like response times. The guide encourages agencies to collaborate with other organizations to share insights and improve care quality. It concludes with recommendations for integrating new technologies and data sources to enhance patient monitoring and care delivery.