This document is a guide that outlines Title-Based Targeting (TBT) as a new approach for B2B marketers to address the challenges of accessing decision-makers at scale. TBT utilizes advanced natural language processing and keyword intelligence to enable marketers to reach individuals based on their job titles, industries, company affiliations, experience, and seniority. The guide details how TBT provides coverage of over 90 million employee positions, allowing for precise identification and targeting of the right audiences. It discusses the limitations of traditional cookie-based methods, which often yield low match rates, and emphasizes the advantages of TBT in achieving higher match rates through a cookie-free data onboarding process. The document also describes the AudienceDesigner platform by Semcasting, which facilitates the activation of first-party data and supports marketers in building effective B2B campaigns across various digital channels. Overall, the guide presents TBT as a strategic solution for enhancing lead generation and campaign success in B2B marketing.